SCHLANGENGIFTimpfschaden Ö
7.6.2022: Hirnschaden: "Creutzfeldt-Jakob-Krankheit als
Folge der Covid-Impfung"
https://tkp.at/2022/06/07/creutzfeldt-jakob-krankheit-als-folge-der-covid-impfung/
Creutzfeldt-Jakob-Krankheit=Auflösung des Gehirns:
https://de.wikipedia.org/wiki/Creutzfeldt-Jakob-Krankheit
Es scheint kein
Ende zu nehmen mit den Nebenwirkungen und längerfristigen
Schädigungen durch die massenhaft angewendeten
Covid-Impfstoffe. Nun taucht noch eine besonders
gefürchtete Krankheit in einer noch nie gekannten
Schnelligkeit und Schwere auf. Sie war schon vermutet
worden, da durch das Spiken gebildete Prione gefunden
worden waren.
Die
klassische Creutzfeldt-Jakob-Krankheit (CJK) ist eine beim
Menschen sehr selten auftretende, tödlich verlaufende
Enzephalopathie. Charakteristisch für die Krankheit ist,
dass die abnorm gefalteten Prionproteine vor allem im
Gehirn den dort normalerweise vorhandenen „Vettern“ mit
gesunder Struktur ihre veränderte Struktur aufzwingen und
so dort einen verhängnisvollen biochemischen Prozess
auslösen, der letztlich zu einer Degeneration des Gehirns
führt. Die krankhaft gefalteten Proteine lagern sich in
Nervenzellen ab und bilden Klumpen. Die Funktion der
Nervenzellen wird zunehmend gestört, sodass es bis hin zum
programmierten Zelltod kommt (Apoptose).
Die
Möglichkeit, dass diese Krankheit durch die mRNA-Vakzine
auftreten kann, wurden bereits am 27. Dezember 2020 in
einem Research Artikel mit dem Titel „COVID-19 RNA Based
Vaccines and the Risk of Prion Disease“ thematisiert. Mehr
dazu in diesem
Bericht. Eine Studie von Yale hatte gezeigt, dass
die Impf-Spikes direkt das
Gehirn infizieren können.
In diesem Artikel
haben wir beschrieben, dass die Bildung von
Amyloiden, eben diese fehlgefalteten Proteine, nicht selten
sind und auf verschiedenen Wegen im Gehirn durch die
mRNA-Impfung produziert werden. Prionen sind vereinfacht
formuliert Amyloide, die die Bildung weiterer Amyloide
auslösen – also eine Kettenreaktion. Allgemein einer
breiteren Öffentlichkeit bekannt wurden Prionen im Rahmen
der BSE-Krise, da sie die Creutzfeld-Jacob-Krankheit
auslösen können.
In einer neuen französischen
Studie, an der noch der heuer im Februar verstorbene
Luc Montagnier beteiligt war, werden anhand von 26 Fällen
die Zusammenhänge von CJK und dem für die impfungen
verwendeten Spike Protein untsucht.
Der Titel:
„Towards
the emergence of a new form of the neurodegenerative
Creutzfeldt-Jakob disease: Twenty six cases of CJD
declared a few days after a COVID-19 “vaccine” Jab“ (Auf dem Weg zum
Auftreten einer neuen Form der neurodegenerativen
Creutzfeldt-Jakob-Krankheit: Sechsundzwanzig Fälle von
CJK, die wenige Tage nach einer COVID-19-„Impfstoff“
Spritze gemeldet wurden)
Die Studie
verweist auf das
Vorhandensein einer Prion-Region in den verschiedenen
Spike-Proteinen des ursprünglichen SARS-CoV2-Virus sowie
in allen seinen nachfolgenden Varianten, aber auch in
allen „Impfstoffen“ hin, die auf derselben Sequenz des
Spike-SARS-CoV2 aus Wuhan aufbauen.
Paradoxerweise
verschwindet die mögliche Schädlichkeit dieser
Prion-Region in der Omicron-Variante mit einer achtmal
höheren Mutationsdichte als im Rest des Spikes
vollständig.Die Ursachen für dieses Verschwinden der
Prion-Region des Spike von Omicron wird analysiert
und erklärt.
Weiter
beschäftigt sich die Studie mit dem Zusammentreffen
von Fällen, die in verschiedenen europäischen Ländern
aufgetreten sind. Dabei zeigte sich, dass nach den ersten
Dosen des mRNA-Impfstoffs von Pfizer oder Moderna ein plötzliches und schnelles Auftreten der
ersten Symptome der Creutzfeldt-Jakob-Krankheit zu beobachten
war. Das dauert normalerweise mehrere Jahre.
Innerhalb
weniger Wochen sind in Frankreich und Europa mehr als 50
Fälle von fast spontanem Auftreten der
Creutzfeldt-Jakob-Krankheit kurz nach der Injektion der
ersten oder zweiten Dosis der Impfstoffe von Pfizer,
Moderna oder AstraZeneka aufgetreten. Zusammenfassend
lässt sich sagen, dass bei den 26 analysierten Fällen die
ersten Symptome der CJK im Durchschnitt 11,38 Tage nach
der Injektion des COVID-19-„Impfstoffs“ auftraten. Von
diesen 26 Fällen waren 20 zum Zeitpunkt der Abfassung
dieses Artikels bereits verstorben, während 6 noch am
Leben waren. Die 20 Todesfälle traten nur 4,76 Monate nach
der Injektion auf. Bei 8 von ihnen trat ein plötzlicher
Tod ein (2,5 Monate). All dies bestätigt die radikal
andere Natur dieser neuen Form der CJK, während die
klassische Form mehrere Jahrzehnte benötigt.
Es ist
ziemlich erschütternd die Fallbeschreibungen in Table 8
(Seite 36 zu lesen).
SCHLANGENGIFTimpfschaden weltweit 16.6.2022:
Montagnier-Studie über Creutzfeldt-Jakob-Krankheit nach
"Coronaimpfung" gelöscht - ist im Archiv weiter
erreichbar:
ResearchGate löscht Studie mit Luc
Montagnier über Creutzfeldt-Jakob-Erkrankungen nach
Impfung
https://tkp.at/2022/06/16/researchgate-loescht-studie-mit-luc-montagnier-ueber-creutzfeldt-jakob-erkrankungen-nach-impfung/
Hier ist die Studie im Archiv:
https://web.archive.org/web/20220610073726/https://www.researchgate.net/publication/358661859_Towards_the_emergence_of_a_new_form_of_the_neurodegenerative_Creutzfeldt-Jakob_disease_Twenty_six_cases_of_CJD_declared_a_few_days_after_a_COVID-19_vaccine_Jab
16.6.2022:
Creutzfeld-Jakob nach COVID-19 Impfung: Die Belege werden
zahlreicher
https://sciencefiles.org/2022/06/11/creutzfeld-jakob-nach-covid-19-impfung-die-belege-werden-zahlreicher/
Towards
the emergence of a new form of the
neurodegenerative
Creutzfeldt-Jakob disease:
Twenty
six cases of CJD declared a few days
after a
COVID-19 “vaccine” Jab
Jean
Claude Perez, PhD Maths§Computer Science
Bordeaux University ; Retired (IBM
European
Research center on Artificial
Intelligence Montpellier France) ; Bordeaux
metropole
France; https://orcid.org/0000-0001-6446-2042 France
jeanclaudeperez2@gmail.com
Claire
Moret-Chalmin, MD. Neurologist, 13 rue
Roger Martin du Gard 60600 Clermont
France clmoret@gmail.com
Luc
Montagnier R.I.P MD. Virologist, Fondation Luc Montagnier Quai Gustave-Ador 62 1207
Genève,
Switzerland
KEYWORDS
Creutzfeldt-Jakob desease (CJD), Prion protein, SARS-CoV2 Variants,
Spike,
COVID-19
mRNA Vaccines, survival,
Neuropsychiatric disease, Evolution.
ABSTRACT
We
highlight the presence of a Prion
region in the different Spike proteins
of the
original
SARS-CoV2 virus
as well
as of
all its
successive variants
but also
of all
the “vaccines” built on this same sequence of the Spike SARS-CoV2 from
Wuhan.
Paradoxically, with
a density of
mutations 8
times greater than that of the rest
of the spike,
the possible
harmfulness of this Prion region
disappears
completely
in the
Omicron variant.
We analyze and explain
the causes of this
disappearance
of the Prion region of the Spike
of Omicron.
At the
same time, we
are analyzing the concomitance
of cases, which occurred
in various European countries, between the first doses of Pfizer or Moderna
mRNA vaccine and the sudden and rapid onset of the first symptoms of
Creutzfeldt-Jakob
disease,
which usually requires several
years before
observing
its first symptoms.
We are studying 26 Creutzfeld
Jakob
Diseases,
in 2021,
from an anamnestic
point of
view, centered on the chronological aspect of the
evolution of this new
prion
disease, without being able to have an explanation of
the etiopathogenic
aspect of this new entity. We subsequently
recall
the
usual history of this
dreadfull subacute disease, and compare it with this new, extremely acute,
prion disease,
following
closely
vaccinations. In a few weeks, more 50 cases of
almost spontaneous emergence of Creutzfeldt-Jakob disease have appeared in France
and Europe very
soon after
the injection
of the
first or
second dose
of Pfizer, Moderna or
AstraZeneka vaccines. To summarize,
of the 26 cases analyzed,
the
first
symptoms
of
CJD appeared
on
average 11.38 days
after the injection
of
the
COVID-19 "vaccine".
Of
these
26 cases, 20 had died at the time of writing this
article while 6 were still alive. The 20
deaths occurred only 4.76 months after the
injection. Among
them,
8
of
them
lead
to
a
sudden
death (2.5 months). All this confirms
the radically different
nature of this new form
of
CJD, whereas the classic form requires several
decades.
CONTENTS
I-INTRODUCTION
II-METHODS
2.1-
PLAAC analysis
2.2-
Master Code analysis
III-RESULTS and DISCUSSION
3.1- Different research for Prions in representative
species: PRNP in humans,
cows
(mad cow disease) and sheep as well as Prion
TDP-43.
3.2
– How the Prion
function present in the
Spike proteins of strains, variants or
vaccines, all based on the Wuhan parent strain, disappears in the Omicron
variant
3.3 - Possible Prion functions in 25 Spike proteins from SARS-CoV2 strains,
variants or
“vaccines” representative
of
the evolution of
the
SARS-CoV2 virus
pandemic.
3.4- TWENTY
SIX (26) cases
of patients for
whom the Creutzfeldt-Jakob
symptoms
appeared within a
very short time after
Pfizer, Moderna or
AstraZeneca
injections.
IV-CONCLUSIONS
I-
INTRODUCTION
Prions are self-templating protein aggregates that stably perpetuate distinct biological
states
(Lancaster et al, 2014).
In
(Prusiner S, 1997) there
was a
good
definition of Prion
basic
research breakthough:
«Creutzfeldt-Jakob
disease and related illnesses affecting people and
animals involve the
degeneration of brain cells. In 1982 Stanley Prusiner was able to isolate a suspected
infectious
agent, a protein that
he called
a
prion. He identified
the gene
behind
the prion
protein, but determined that it is also present in healthy people and animals. Stanley
Prusiner showed
that
the prion molecules are folded in a
different way than the normal
proteins
and that the folding of the prion can
be transferred to normal proteins. This is the
basis
for the illness».
Finally,
to resume, Prions are proteins
that can switch from
non-aggregated states
to self-
templating
highly ordered
aggregates. This
property allows them to confer
stable changes
in
biological states.
In
(Tetz§Tetz, 2022), (Seneff&Nigh, 2021) and (Classen, 2021), it
has been demonstrated,
or
at least suggested,
the presence of a
Prion region in
all Spike proteins
of SARS-CoV2
viruses.
In (Seneff&Nigh,
2021), Dr. Stephanie
Seneff, who
works in the Computer Science and
Artificial
Intelligence Laboratory at the Massachusetts
Institute of Technology
(MIT), along
with colleague Greg Nigh from Naturopathic Oncology in Portland, Ore., identified a
“GxxxG signature motif” within
the injections
that they
say increases the risk
that
misfolding will occur, creating toxic oligomers. They call this the “glycine zipper motif”,
characterized by a pattern of two
glycine residues spaced by three
intervening amino acids,
represented
as GxxxG.
Particularly, the bovine
prion linked to
MADCOW has, also,
a spectacular
sequence of ten GxxxGs in a row …
Similarly,
the
SARS-CoV2 spike transmembrane protein
contains five GxxxG motifs in its sequence. Then, it
becomes extremely
plausible that it could
behave
as a prion.
This
presence of Prion region has been formally demonstrated, (Tetz§Tetz,
2022) but does
it
actually produce a possible behavior in "Prion
Function" of these Spikes?
The answer seems to be "Yes"
(Kuvandyk A, 2021), (Idrees D, 2021) and (Young M,
2020).
Indeed - and this
will
be the subject of this article – in a few weeks, more 50 cases of
almost spontaneous emergence of Creutzfeldt-Jakob disease have appeared in France
very
soon after the injection of the first or second
dose of Pfizer vaccines or Moderna.
Usually
this
disease takes decades to
manifest itself. Why and
how
can
this
same
fatal
disease declare itself so quickly following these injections? It is very likely that we are
dealing
here with a new form of Creutzfeldt-Jakob disease.
II-
METHODS
We
will use 2 complementary methods of prion
analysis:
-The
first is the PLAAC software
(Lancaster et al, 2014) which makes
it possible
to detect, from an amino acid sequence,
regions likely to develop a prion
function.
-The
second is the “Master Code of DNA” (Perez, 2009), (Perez,
2015) and
(Perez§Montagnier, 2021)
making it possible
to
confirm or reinforce the
hypothesis of a possible prion function
by
highlighting certain structures or
patterns of
the curves of
the Master Code unifying the
Genomics and
Proteomics
signatures of the sequence considered.
2.1-
PLAAC analysis:
We
illustrate the method here
using the example of
the
SUP35 Prion from
the
yeast.
Saccharomyces
cerevisiae S288C translation termination factor
GTPase eRF3
(SUP35),
partial mRNA
NCBI
Reference Sequence: NM_001180479.3
https://www.ncbi.nlm.nih.gov/nuccore/398365952
Figure 1
-
Visualization outputs from PLAAC.
Top: four known yeast prion
proteins with
each amino
acid
color-coded by
its
enrichment log-likelihood ratio
in
PrLDs
(styled after
the Sequence Enrichment Visualization Tool; http://jura.wi.mit.edu/cgi-
bin/bio/draw_enrichment.pl), with
HMM
parse indicated by outer bars. Bottom: detailed
visualization
of
the Yeast Sup35 protein,
including several prion-prediction scores.
source
(Lancaster
et al, 2014).
In
Figure
1 above
we analyze
the Sup35
yeast prion (Kushnirov V,
2000) using
the
PLAAC software.
The
PLAAC
software detects a Prion
region which would
be
located in the first
120
amino acids of the SUP35
protein. This is confirmed by the red curve at the
top
of the image, as well
as by the red curve and the gray part of the curves at
the
bottom of the image (see Legends Figure 2 and Table
1 below).
Table 1 – PLAAC
conventions and explanations.
LEGEND
PLAAC results
==>
Top two curves
are
complementary curves resulting from Markov chain
process (Markov A.A, 1971)
Background Black ------
PrD
like Red +++++
==>
Bottom three curves
Fold
index gray ----- (entropy
like indicator). Low (negative) if possible
Prion function
PLAAC Red ----- Low (negative) if
possible Prion function
PAPA
Green second
complementary method. High if states
transitions
Figure
2 – PLAAC colors
conventions and explanations.
2.2-
Master Code analysis :
The
so-called "Master
Code" method (Perez, 2009), (Perez, 2015) and
(Perez§Montagnier, 2021) allows, from the only atomic masses common to
DNA,
RNA and amino acids numerical
values, to highlight a kind
of META-CODE
which
would unify the 3 codes of DNA, RNA and amino acid
sequences.
Particularly, the
Master code curves
measure the level of
coupling or
correlation unifying the
2
Genomics (DNA) and
Proteomics (amino acids)
expressions
for any sequence, coding for a protein, or not.
In
(Perez, 2017a) we analyzed all
types
of
Prions in the early 2000s
mad
cow
disease
(plants, yeast,
humans, cows, sheep,
etc.).
We had then highlighted a
kind
of "signature" or invariant
which would be
common to all
Prions: a typical
signature
of the Master code taking the characteristic form
of a "W" (or even by
symmetry of an "M"). We had extended this type of analysis to amyloid
implicated
in Alzheimer's disease (Perez, 2017b).
Figure
3 – "W" structure, kind of INVARIANT COMMON to all
Prions (here the case of the
human
PRNP Prion).
Figure
4 – "W" pattern structure
and "decreasing" region of the Yeast Sup35 Prion "Master
code"
image.
It is through the joint and complementary use of the Prions PLAAC
research
software,
on the one
hand,
and
of the "Master
code",
on the other
hand,
that
we will succeed in this article in detecting and then confirming the possible
presence,
even probable, of a Prion function.
Thus, the first PLAAC method
"proposes" a probable Prion
function.
The second method of the "Master Code", on
the one hand,
"confirms" the
structure
in
"W" or, symmetrically, in
"M"
for
the regions
proposed by PLAAC,
then,
on
the other hand,
we
observe that these regions
Prion from PLAAC are
always confirmed by
"continuously
decreasing" on the "Master code" curves
(see
exemple Figure 6).
III-
RESULTS and DISCUSSION
First,
we present different studies
of Prions in
representative species: man, cow
(mad
cow disease) and sheep.
In
a second
step, we prove
the disappearance of
the possible Prion
function in
the
last Omicron
variant while this
function is highlighted in the Wuhan parent
strain, but also in ALL the other variants and in ALL the "injection vaccines"
Pfizer,
Moderna, etc.).
Then, in a third step, we are looking for possible Prion functions in 25 Spike
proteins
of
strains, variants or
vaccines representative
of the evolution of
the
SARS-CoV2 virus pandemic from Wuhan initial strain to the last Omicron
worldwide
variant.
Finally, we present SIXTEEN cases of French,
Belgium, Switzerland and Israel
patients for whom Creutzfeldt-Jakob symptoms appeared within a very short
time
after Pfizer or Moderna injections.
3.1- Different research for Prions in representative species:
PRNP
in humans,
cows
(mad cow disease) and sheep as well as Prion
TDP-43.
3.11
– The HUMAN PRNP PRION
https://www.ncbi.nlm.nih.gov/nuccore/AF085477.2
Homo
sapiens prion protein precursor
(PRNP) gene, complete cds
GenBank:
AF085477.2
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPH
GGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPS
KPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQN
NFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLI
FLIVG
PLAAC
http://plaac.wi.mit.edu
Figure
5 – PLAAC analysis of the Human
PRNP Prion. Evidence of a Prion region
between
amino acids 30-120.
Figure
6 – Confirmation of Human
PRNP Prion region by the Master code.
3-12– The OVIS PRION (Sheep)
Prion
https://www.ncbi.nlm.nih.gov/protein/NP_001009481.1?report=fasta
major
prion protein precursor [Ovis aries]
NCBI
Reference Sequence: NP_001009481.1
GenPept Identical
Proteins Graphics
>NP_001009481.1
major prion protein
precursor [Ovis aries]
MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQ
PHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRP
LIHFGNDYEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITVKQHTVTTTTKGENFTETDIKIME
RVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG
PLAAC
http://plaac.wi.mit.edu
Figure
7 – PLAAC analysis of the Ovis
Sheep Prion. Evidence of a Prion region between
amino
acids 40-90 and perhaps 160-180
-nucleotides
https://www.ncbi.nlm.nih.gov/nuccore/NM_001009481.1?report=fasta
Ovis
aries prion protein (PRNP),
mRNA
NCBI
Reference Sequence: NM_001009481.1
>NM_001009481.1
Ovis aries prion protein
(PRNP), mRNA
CDS 161..931
/gene="PRNP"
/gene_synonym="prion; Prp; PRPC; SIP"
/note="major prion protein; prion protein (p27-30)
(Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker
syndrome, fatal familial insomnia)"
/codon_start=1
/product="major prion protein precursor"
/protein_id="NP_001009481.1"
/db_xref="GeneID:493887"
/translation="MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQ
GSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQW
NKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRY
PNQVYYRPVDQYSNQNNFVHDCVNITVKQHTVTTTTKGENFTETDIKIMERVVEQMCI
TQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG"
Figure
8 – Confirmation of Ovis
(Sheep) Prion region by the Master code.
3.13- The BOS TAURUS (Cow) Prion
https://www.ncbi.nlm.nih.gov/nuccore/AB457178.1
Bos
taurus prn mRNA for prion protein, complete cds
GenBank:
AB457178.1
gene 1..1352
/gene="prn"
CDS 11..805
/gene="prn"
/note="alternative splicing: see also Acc# AB457179.1"
/codon_start=1
/product="prion protein"
/protein_id="BBD75290.1"
/translation="MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQ
GSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWG
QGGTHGQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGSDYEDRY
YRENMHRYPNQVYYRPVDQYSNQNNFVHDCVNITVKEHTVTTTTKGENFTETD
PLAAC
http://plaac.wi.mit.edu
Figure
9 – PLAAC analysis of the Bos Taurus (Cow) Prion.
Evidence of a Prion region
between
amino acids 40-90 and perhaps 170-180P
Figure
10 – Confirmation of Bos Taurus (Cow) Prion region
by the Master code.
3.14- Other Prion risk : TDP-43 Prions
In
(Classen, 2021), author suggests the spike protein
target interaction were analyzed for the
potential
to
convert intracellular RNA binding proteins TAR DNA
binding protein (TDP-43)
and
Fused
in Sarcoma (FUS) into their pathologic prion
conformations.
Here
we analyse TDP-43 Prion properties (Takashi Nonaka et al, 2013)
and (Luke McAlary, 2019).
TDP-43
https://www.ncbi.nlm.nih.gov/gene?term=(tdp43[gene])%20AND%20(Homo%20sapiens[orgn])
%20AND%20alive[prop]%20NOT%20newentry[gene]&sort=weight
TARDBP
TAR DNA binding protein
[ Homo sapiens (human) ]
Gene
ID: 23435,
https://www.ncbi.nlm.nih.gov/nuccore/NM_007375.4
Homo
sapiens TAR DNA binding protein (TARDBP), mRNA
NCBI
Reference Sequence: NM_007375.4
CDS 103..1347
/gene="TARDBP"
/gene_synonym="ALS10; TDP-43"
/note="TAR DNA-binding protein-43"
/codon_start=1
/product="TAR DNA-binding protein 43"
/protein_id="NP_031401.1"
/db_xref="CCDS:CCDS122.1"
/db_xref="GeneID:23435"
/db_xref="HGNC:HGNC:11571"
/db_xref="MIM:605078"
/translation="MSEYIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYR
NPVSQCMRGVRLVEGILHAPDAGWGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQK
TSDLIVLGLPWKTTEQDLKEYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVK
VMSQRHMIDGRWCDCKLPNSKQSQDEPLRSRKVFVGRCTEDMTEDELREFFSQYGDVM
DVFIPKPFRAFAFVTFADDQIAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGRF
GGNPGGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSW
GMMGMLASQQNQSGPSGNNQNQGNMQREPNQAFGSGNNSYSGSNSGAAIGWGSASNAG
SGSGFNGGFGSSMDSKSSGWGM"
PLAAC
http://plaac.wi.mit.edu
Figure
11 – PLAAC analysis of the TDP-43 Human Prion.
Evidence of a Prion region
between
amino acids 280-390.
Figure
12 – Confirmation of Human
TDP-43 Prion region by the Master code.
3.2
– How the Prion
function present in the
Spike proteins of strains,
variants or
vaccines,
all based on the Wuhan parent strain, disappears
in the Omicron variant
ZOOM on the 38 amino acids (473-510) WINDOW
PRION from SPIKE WUHAN
PLAAC
http://plaac.wi.mit.edu
REGIONPRIONWUHAN
SKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNG
VGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVN
Figure
13 – PLAAC evidence of a
Prion region in the 100 amino acids region
overlaping
Wuhan
Prion region.
Figure
14 – Master code
confirmation of a Prion region in the 100 amino
acids region
overlaping
Wuhan Prion region.
ZOOM on the 38 amino acids (473-510) WINDOW
PRION from SPIKE Omicron
PLAAC
http://plaac.wi.mit.edu
SKVSGNYNYLYRLFRKSNLKPFERDISTEIYQAGNKPCNGVAGFNCYFPLRSYSFRPTYG
VGHQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVN
Figure
15 – PLAAC evidence that
Prion region in the 100 amino acids region
overlaping
Omicron
Prion region disappears totally.
Zoom
analysis of the 38 amino acids
of the Prion regions between Spikes Wuhan
and
Omicron
It seemed interesting to us to analyze the incidence of the 8 amino acid
mutations located in the Prion region (amino acids 473 to 510 of the Spike)
which
differentiate the Wuhan parent
strain and the latest Omicron variant.
Let's
remember these 8 mutations:
see
https://covariants.org/variants/21K.Omicron
S:S477N
S:T478K
S:E484A
S:Q493R
S:G496S
S:Q498R
S:N501Y
S:Y505H
OMICRON
PRION SPIKE
Nucleotides
Prion region (114 bases)
:
TATCAGGCCGGTAACAAACCTTGTAATGGTGTTGCAGGTTTTAATTGTTACTTTCCTTTACGATCATATAGT
TTCCGACCCACTTATGGTGTTGGTCACCAACCATACAGAGTA
Amino
acids Prion region (38 amino acids)
473 510
YQAGNKPCNGVAGFNCYFPLRSYSFRPTYGVGHQPYRV
XX X X X X X X
PLAAC analysis of this 38 amino
acid
sequence demonstrates the TOTAL
disappearance
of
the
Prion function although the presence
of
these
38 amino
acids
is conserved in positions in the Omicron Spike protein.
Figure
16 – The Prion function
disappears totally in Omicron variant.
Now
let's perform the same
analysis on the Wuhan parent
strain. Let us recall
here that all the COVID-19 vaccines having been injected into hundreds of
millions
of humans to date have been
constructed from this same
sequence of
the
Wuhan Spike.
WUHANPRION SPIKE
Nucleotides
Prion region (114 bases)
:
ZOOMPRIONWUHAN <== SPIKREF[1416 on 114]
ZOOMPRIONWUHAN
TATCAGGCCGGTAGCACACCTTGTAATGGTGTTGAAGGTTTTAATTGTTACTTTCCTTTACAATCATATGGT
TTCCAACCCACTAATGGTGTTGGTTACCAACCATACAGAGTA
Amino
acids Prion region (38 amino acids)
473 510
YQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRV
Figure
17 – The Prion function is
present in the Wuhan initial sequence.
Here,
contrary to the case of
Omicron, the potential function of the Prion is well
revealed
by the PLAAC software.
Let's find the "PLAAC distance" between the 2 respective results Omicron and
Wuhan:
Figure
18 – Prion nature
classification hierarchy between the 20 amino
acids.
- + - + + + + +
WUHAN
YQAG ST PCNGV E GFNCYFPL
Q SY G F Q PT N GVG Y
QPYRV
OMICRON
YQAG NK PCNGV A GFNCYFPL
R SY S
F R PT Y GVG H
QPYRV
+ - + - - - - -
Distances
- 7 10 2 10 2 6 ==>
- 37
Distances
+ 5 12 ==> + 17
Difference
reinforcing Prion function : - 20
We
can now conclude by
asserting that the 8
amino acid mutations,
or 21%
of
this small region have ACTUALLY
caused the TOTAL
DISAPPEARANCE of the
Prion
function. Two questions
remain "open":
1/ Was this Prion
region "natural" or chimerical when the Wuhan
virus emerged?
2/ Was this suppression of the
Prion function natural following
the "humanization"
of the
virus or
was it provoked? This question also remains "open"...
3.3 - Possible Prion functions in 25 Spike proteins from SARS-CoV2 strains,
variants or “vaccines” representative of the evolution of the SARS-CoV2
virus
pandemic.
We
studied the Spike sequences of 25 SARS-CoV2
genomes. In these Spikes
we
searched
for the presence of possible regions likely to
have the functionality of
a Prion. For this we use
the
PLAAC bioinformatics software (Lancaster et al,
2014)
and “Master code” (Perez§Montagnier, 2021).
Let
us
recall here the
8 amino acid
mutations differentiating
the Prion
regions
from
the Spikes of Wuhan SARS-CoV2 and Omicron.
Figure 19 –The 8
amino acid mutations differentiating the Prion regions from Wuhan
SARS-CoV2
and Omicron Spikes.
Figure 20 below shows the Genomics/Proteomics image of the Master code
relating
to the
region of 100 amino
acids flanking the small
Prion region of 38
amino
acids.
Figure
20 – Genomics/Proteomics image of
the Master code relating to the
region of 100
amino
acids flanking the small Prion region of 38 amino
acids.
3.31-Analysing the main 10 SARS-CoV2 and
variants representative strains
Both
Figures 21 to 24
demonstrate via
both
PLAAC
software and Master Code
method
the presence
of the
Prion region around amino acids
500 of
the Spike.
We
see that this Prion is present in the DELTA
variant (Figure 21) but also in the
Pfizer and Moderna vaccines (Figures
22-24) since ALL these vaccines were
built
from the Spike of SARS-CoV2 Wuhan.
Figure
21 – PLAAC software
demonstrates the presence of the Prion region
around amino
acids
500 of the spike of the DELTA variant.
PFIZER
« Vaccine » Spike
Figure
22 – PLAAC software
demonstrates the presence of the Prion region
around amino
acids
500 of the spike of both vaccine Pfizer.
Figure 23 – The Master
Code method provides a global analyzes of the
roughness or
fractal
texture of both Genomics (Red) and Proteomics
(Blue) of the Spike Prion region.
As
demonstrated in
(Perez, 2021a), it
can
be
seen that, compared to
that
of
Figure 20
(Wuhan
Spike Prion region), the Prion region of
the
Pfizer vaccine has a highly chaotic
Master code curves at
the level of fractal roughness (Genomics in particular). This
roughness
results from the "G"
base doping
of this sequence,
the purpose
of which is
to
increase the stability of the mRNA without changing the amino acids (by
using the
vagueness
allowed by the genetic code in the translation
codons <==> amino acids ).
(see (Perez, 2021a).
Running
now a similar analysis for MODERNA vaccine.
MODERNA
Vaccine Spike
MFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNG
TKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNN
KSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSAL
EPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSE
TKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASF
STFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGG
NYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAP
ATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVS
VITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGIC
ASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTE
CSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDLLFN
KVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPF
AMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFG
AISSVLNDILSRLDPPEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKG
YHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNT
FVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLN
ESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGV
KLHYT
Figure
24 – PLAAC software
demonstrates the presence of the Prion region
around amino
acids
500 of the spike of both vaccine Moderna.
Table 2
–
Presence
of the
Prion region in ALL historical SARS-CoV2 Spikes
excepted in
Bat
RaTG13.
Identification of main SARS-CoV2,
variants and vaccines
PRION region
amino acids 473-510
Notes
SARS-CoV2
Wuhan
YES
ALPHA
(UK) YES
BETA (South Africa) YES
GAMMA
(Brazil) YES
DELTA
(India) YES
mRNA vaccins Pfizer YES
mRNA vaccins Moderna YES
batRaTG13 NO Prion
region totally absent
ScovZC45 YES (shifted) In the 50 first amino
acids
ScovZXC21 YES (shifted) In the 50 first amino
acids
We note that the Prion region does not exist in
the Bat RaTG13.
Curiously, the Prion
region
is also present
in ScovZC45 and
ScovZXC21 but this
Prion region is
located
within the 50 first Spike amino acids and not in
the 500 amino acids area. Why ?
3.32-Analysing
the seven first Omicron worldwide patients cases.
We
are
now
studying the very first cases of patients with Omicron, in South
Africa,
Europe and the USA and Canada in particular. In ALL of these cases,
the
Prion
region has disappeared.
Table 3 –
The
seven first Omicron worldwide patient strains cases where the Prion region
function
disappears totally in ALL
cases.
Ref Identification
of first Omicron worldwide patient strains Prion
region
SOSA1
One of the 3 first cases in
South Africa none
SOSA2
One of the 3 first cases in
South Africa none
SOSA3
One of the 3 first cases in
South Africa none
SOBEL
First case in Belgium none
SOCAN First case in
Canada none
SOMIN Second case in
USA and first case in Minesota
none
SUK First case in UK none
Results None
3.33-Analysing 8 USA Omicron patients
randomly selected from
Genbank.
Finally,
we study eight
cases of patients affected
by Omicron and coming
from
different
states in the USA. In
ALL of these 8 cases,
again, the Prion region has
disappeared.
Figure
25 – PLAAC analysis of the
Omicron Texas patient
strain show that the Prion
region
disappears totally.
Table 4 – PLAAC
analysis of seven Omicron from various USA States patients strains
show
that the Prion region disappears totally in ALL cases.
Ref Identification
Omicron USA patient
strain Prion region
SUSA1
Sequence ID: OM084744.1 USA/KY none
SUSA2 Sequence ID: OM084702.1 USA/KY none
SUSA3 Sequence ID:
OM084601.1
USA/TN none
SUSA4
Sequence ID: OM084601.1 USA/TN none
SUSA5 Sequence ID:
OM084538.1
USA/KY none
SUSA6
Sequence ID: OM084529.1 USA/IN none
SUSA7 Sequence ID:
OM084430.1
USA/OH none
SUSA8
Sequence ID: OM084409.1 USA/TX none
Results None
3.34
- Meaning of the W or M structures of the Prion
Master Code images
We
observed that all
the Prions had Master
Code images patterns in “W” or in
“M”, on the one hand, but also, on the other hand, that the Prion regions
detected
by PLAAC corresponded to descending parts of these
images.
Several years ago we had the idea of imagining a kind of hypothetical gene
which would be formed by the sequence of the 64 codons of the universal
genetic code.
What
then would have been
his
Genomics/Proteomics signature
of
the Master Code? This is the image in Figure 25 below.
Curiously,
we notice that it too has an “M” shape.
Figure
26 – « M »
shape running Master Code on the Universal
Genetic Code 64 codons
synthetic
gene.
In
the Table of the Genetic
Code (Figure
26 right),
the codons
are classified
according to
the
regular order TCAG. We also observe
(Figure 26 left) that it
is the second base of
the
codon triplets that dictates the meta structure of the Master Code image following the
TCAG
meta-order. Consequently
the 2
descending regions of
“M” patterns
are the
C and
G
bases.
To
come
back to the Prions, this therefore means that
the
Prion regions
detected
by PLAAC are regions in
which the CG richness of the
double strand of
DNA
increases, producing this regular "descending"
shape.
Finally, let us note that the mRNA vaccines Pfiser and Moderna were doped
with CG bases without modifying the corresponding amino acids (using the
vagueness allowed by the Genetic Code). So, although their Prion region
remains identical to that of the initial Wuhan Spike strain at the amino acid
level,
one
can think that this
CG base
doping
could amplify the
Prion effect of
vaccines if some unknown information (energy, dynamics?) is transmitted
during
the translation of mRNA into amino acids.
Figure 27 – Comparing Master code pattern Genomics/Proteomics signatures between
both
Spike Prion regions in SARS-CoV2 Wuhan and
Omicron.
Although
the 2 Master
code images
of
the 2
respective Prion regions
of SARS-
CoV2 Wuhan and Omicron appear very similar, we note however that the
transition
of this region
from Wuhan to
Omicron results from the 8
amino acid
mutations of this Prion region
produced an improvement of more
than 2% of
the
Genomics/Proteomics coupling 88.45% ==> 90.63%.
What we interpret as a better adaptation of the Omicron virus vis-à-vis its
human
host.
It is interesting to discuss the relevance and consistency of this Prion region
highlighting
in the
spikes of all pre-Omicron variants as well
as in
the spikes of
all
COVID-19 vaccines.
The weak point of these results is that they remain qualitative. We lack a
quantitative
basis for comparison here.
For
example, the PLAAC
amplitude of this Prion
region
of SARS-CoV2 remains
low
compared to the same analysis performed on the
human prion PRNP.
Fortunately,
what would
reinforce our discovery
is a
kind of proof by inhibition
or negation: indeed we demonstrate how and by which mutations this Prion
region
could disappear... and, indeed, how it
disappeared from ALL the Omicron
variants
analyzed.
This type of proof, then, becomes
very strong: "it's by analogy a bit like using the
shadow to prove the existence of light..."
Alas,
the actual cases
of Creutzfeldt-Jakob-like illnesses soon
after the
injections of
Covid-19 vaccines that will be
presented now will
prove that the
hypothetical
Prion function that we have just detected does
indeed exist.
3.35
- A possible path towards understanding the Prion
effect.
Let's
look at the well-known table of the universal
Genetic Code:
Figure
28 – The Universal Genetic
Code T C A G two
dimensions Table and
the relative
locations
of NQYG Prion facilitators amino acids relating
Stop codons locations.
The idea started
from 2 observations from the
universal genetic code Table.
On the one hand, during
the formation of
a protein from mRNA codons, there is
a trap to avoid: not to "fall" in an anticipated manner on one of the 3 Stop
codons.
On the other hand, if we are interested in NQYG, the 20% of the codons most
favorable to the Prion function, we can think that these amino acids could, by
their biophysical nature, consist of a weak link in the solidity of a structure in
Helix.
We then have the idea of considering the table of the genetic code as the
topology of a 2-dimensional 2D object in which the 3 Stop codons would be a
kind of "hole" in the vicinity
of which
the
slightest mutation of a nucleotide can
pose a problem.
We then have the intuition to locate the 4 amino acids N Q Y G vis-à-vis the
"well" formed by
the 3 Stop codons.
Table 5 – Analysing amino
acids mutations which are located
close codons Stops in the
universal genetic
code table.
N Q Y G the four
amino acids increasing Prion
function
Stop N Q Y G
UAA AAU CAA UAU
UAG AAC CAG UAC
Stop
UGA GGA
Number of
mutations by codon 2 1 1 1
Table 5 above shows that these
4 amino
acids N
Q Y G are
"topologically" close
to the
Stop codons; in 5 of the 7 cases of Stop <==> N Q Y G mutations, a
single mutated
base would suffice. There is the
case for the 3 Prion amino acids
Q Y and G.
In conclusion, this
thesis deserves to be explored to understand
this
mechanism of
Prions.
3.4- TWENTY SIX (26) cases of patients for whom the Creutzfeldt-Jakob
symptoms appeared within a very short
time after
Pfizer
, Moderna
or
AstraZeneca
injections.
In a few weeks, more 50 cases of almost
spontaneous emergence
of Creutzfeldt-Jakob
disease have appeared in France very soon after the injection of the first or second dose
of Pfizer,
Moderna or AstraZeneka
vaccines.
We analyse here
twenty six cases fully documented
at symptoms evolution timing.
Some of the following results were presented at a Neurology congress in
London in March
2022 (Moret-Chalmin et al, 2022).
Alex
K Lancaster
Andrew
Nutter-Upham
Masami
Masuda-Suzukake
Tetsuaki
Arai
Meabh
O'Hare
Marcelo
Matiello
George
Tetz
Afina
Lemstra
M
T van Meegen
Jeroen
P Vreijling
Factors
influencing the survival period in
Japanese patients with sporadic
Creutzfeldt-Jakob disease
- Y
Iwasaki
- A
Akagi
- M
Mimuro
- T
Kitamoto
- M
Yoshida
- V
V Kushnirov
- N
V Kochneva-Pervukhova
- M
B Chechenova
- N
S Frolova
- M
D Ter-Avanesyan
(Iwasaki
Y, 2015), Iwasaki Y, Akagi A, Mimuro
M, Kitamoto T, Yoshida M.Factors
influencing the survival period in
Japanese patients with sporadic
Creutzfeldt-Jakob disease 2015 Oct
15;357(1-2):63-8. ; (Kushnirov V,
2000), Kushnirov VV,
Kochneva-Pervukhova NV, Chechenova MB,
Frolova NS, Ter-Avanesyan MD. Prion
properties of the Sup35 protein of
yeast Pichia methanolica. EMBO J.
2000;19(3):324-331.
doi:10.1093/emboj/19.3.324
Fondation
Luc Montagnier Genève. The case of
DOYER Mauricette and 9 Creutzfeld
Jakob Diseases in 2021
(Moret-Chalmin
C. et al, 2022), Claire T
MORET-CHALMIN, MD, Marc DOYER,
Président de l'Association CJD
(France), Alexandra HENRION CAUDE,
geneticist, Luc MONTAGNIER, Nobel
Prize. Fondation Luc Montagnier
Genève. The case of DOYER Mauricette
and 9 Creutzfeld Jakob Diseases in
2021, 16th World Congress on
Controversies in Neurology CONy to be
held in London in March 24-27,
2022.https://cony2022.comtecmed.com/
(Perez, 2009), Perez J.C, Codex
biogenesis -Les 13 codes de l'ADN
(French Edition) [Jean -Claude...
2009);
Diego
Rapoport
Most
appreciated Prof. Shnoll, happy and honoured to
receive an enquiry of yours. I have recently
completed a 150 pages long article -currently
under reviewal- on the torsion geometry of
physics, b
...
[more]
SCHLANGENGIFTimpfmord
Tessin (Schweiz) 30.7.2022: Frau geimpft: hat Hirnschaden
Rinderwahn (Creutzfeldt-Jakob-Krankheit) - tot:
Eine Frau berichtet, wie ihre Mutter nach der «Impfung»
an Rinderwahn starb
https://transition-news.org/eine-frau-berichtet-wie-ihre-mutter-nach-der-impfung-an-rinderwahn-starb
https://t.me/Impfschaden_Corona_Schweiz/49833
In der Todesanzeige der Frau aus dem
Tessin bedankten sich die Angehörigen beim Neurologen,
«der den Mut hatte, die unerwünschte Wirkung des
Covid-Impfstoffs zu melden».
Am 7. Juli 2022 wurde in Tessiner Zeitungen eine
Todesanzeige veröffentlicht, die Aufmerksamkeit
erregte und in den sozialen Medien viral ging. Der Nachruf
betraf Renata Uccelli aus Lugano, 68 Jahre alt. Die
Besonderheit darin war ein spezielles Dankeschön, das von
ihrer Familie geschrieben wurde. Darin hiess es:
«Besonderer Dank gilt dem Neurologen, der den Mut
hatte, die unerwünschte Wirkung des Covid-Impfstoffs zu
melden, und allen Menschen, die sich um sie gekümmert
haben».
La Bussola Quotidiana ging der Nachricht
auf den Grund und erhielt
von der Tochter von Frau Uccelli eine Bestätigung sowie
Informationen über den Fall. Dabei stellte sich heraus,
dass die Frau an einem fortschreitenden neurologischen
Verfall gestorben war, der durch die Creutzfeldt-Jakob-Krankheit
verursacht wurde – auch als Rinderwahn
bekannt – und unmittelbar nach der Impfung auftrat.
Es handelt sich dabei um eine seltene und
tödliche Krankheit, die das Gehirn angreift und
Demenz und neurologische Schäden verursacht, die sich im
Laufe der Zeit rasch verschlimmern. Offiziell gehört sie
zur Gruppe der übertragbaren spongiformen Enzephalopathien
oder Prionenerkrankungen, die durch eine veränderte
Konformation des zellulären Prionproteins verursacht
werden.
<<
>>
